Attribute Description
Active Ingredient Nifedipine
Dosage Forms 10mg, 20mg
Indications Hypertension, Angina
Storage Store below 25°C
Visit Adalat Page

Pharmacokinetics of Adalat

Adalat, containing nifedipine, plays a vital role in the management of cardiovascular conditions. It belongs to the calcium channel blocker class. Nifedipine 20mg showcases rapid absorption, reaching peak plasma levels in 30 to 60 minutes. Its bioavailability stands at approximately 45-68%, influenced by hepatic first-pass metabolism. The drug’s volume of distribution is substantial, reflecting its extensive tissue distribution.

Binding extensively to plasma proteins, predominantly albumin, nifedipine exhibits a high degree of lipid solubility. This trait facilitates its transit across cell membranes. The elimination half-life of Adalat is relatively short, ranging from 2 to 5 hours. This necessitates controlled-release formulations for sustained therapeutic levels. Metabolism occurs primarily in the liver, with CYP3A4 being the principal enzyme involved. Excretion follows predominantly via urine as inactive metabolites.

Correct Use Guidelines

Proper administration of Adalat ensures optimal therapeutic outcomes. Adalat 20mg should be consumed orally with or without food. Patients should not chew or crush the tablets, as this alters the release mechanism. The dosing schedule is typically once or twice daily, tailored to individual needs and medical advice.

Regular monitoring of blood pressure is essential for patients on Adalat. Dosage adjustments may be necessary based on the therapeutic response and tolerability. Abrupt discontinuation of nifedipine 10mg can lead to rebound hypertension. Gradual tapering under medical supervision is advisable.

FDA-Approved Indications

Adalat is sanctioned by the FDA for the treatment of hypertension and angina. It reduces systemic vascular resistance, aiding in blood pressure management. In angina, it alleviates coronary artery spasms, thus enhancing oxygen delivery to the myocardium.

The use of Adalat 10mg in chronic stable angina is well-documented. It offers relief from chest pain by decreasing cardiac workload. Physicians may prescribe Adalat as part of combination therapy with other antihypertensive agents, expanding its therapeutic scope.

Adalat Storage Recommendations

Proper storage conditions extend Adalat’s efficacy. The drug should be stored at temperatures below 25°C, away from direct sunlight and moisture. It is advisable to keep the medication in its original packaging to protect it from environmental factors.

Adalat should remain inaccessible to children. Any expired or unused medication must be disposed of following pharmacy guidelines. The integrity of the tablets should be checked periodically to ensure their condition remains optimal.

Signs and Symptoms of Adalat Overdose

Overdose symptoms of Adalat demand immediate medical attention. Manifestations include profound hypotension, dizziness, and tachycardia. In severe cases, bradycardia, heart block, or myocardial infarction may occur.

Supportive treatment and symptomatic care form the cornerstone of overdose management. Intravenous fluids, vasopressors, and calcium gluconate may be administered. Gastric lavage or activated charcoal can be employed if the ingestion is recent.

Acquiring Adalat Responsibly

Adalat acquisition should adhere to medical prescriptions. It is vital to consult healthcare professionals for a suitable regimen. This ensures appropriate dosage and mitigates potential side effects.

Online platforms may offer Adalat without a prescription, yet such practices pose risks. Unverified sources might provide counterfeit products. It is prudent to procure Adalat through licensed pharmacies, ensuring authenticity and safety.

Data source: